Search results for "therapy [Ciliopathies]"
showing 10 items of 2852 documents
Neuromuscular fatigue differs following unilateral vs bilateral sustained submaximal contractions
2011
The purpose of the present study was to compare the mechanisms of fatigue induced by a unilateral vs a bilateral submaximal isometric knee extension. Ten physically active men completed two experimental sessions, randomly presented. They were asked to maintain an isometric knee extension force corresponding to 20% of the maximal voluntary contraction (MVC) until task failure with one leg (unilateral) vs two legs (bilateral). MVCs were performed before and after the sustained contraction. Transcutaneous electrical stimuli were used to examine central (voluntary activation) and peripheral (peak doublet force at rest) fatigue on the exercised leg. Time to task failure was significantly shorter…
Changes in motor unit characteristics after eccentric elbow flexor exercise
2010
Morphological evidence suggests that fast-twitch fibers are prone to disruption of their membrane structures by eccentric exercise. However, it is unclear how this is reflected in the discharge rate and action potential propagation of individual motor units, especially at high contraction levels. High-density surface electromyograms were recorded from biceps brachii muscle and decomposed to individual motor unit action potentials at isometric contraction levels between 10% and 75% of maximal voluntary contraction (MVC) before intermittent maximal elbow flexor eccentric exercise, and two hours (2H), two days (2D) and four days (4D) post-exercise. Maximal voluntary force decreased by 21.3±5.6…
Increased Joint Mobility Is Associated With Impaired Transversus Abdominis Contraction.
2020
Mitchell, UH, Owen, PJ, Rantalainen, T, and Belavý, DL. Increased joint mobility is associated with impaired transversus abdominis contraction. J Strength Cond Res 36(9): 2472-2478, 2022-Increased joint mobility is a risk factor for joint injury, but muscle function may be able to compensate for it. Current evidence suggests reduced force production capacity in people with hypermobility. However, little is known about the lumbar spine. The purpose of this cross-sectional study was to assess whether there was a link between joint mobility and transverse abdominis and multifidus muscles contraction, muscles ascribed a core-stability role. Using a modified quantitative version of the Beighton …
Type of sport is related to injury profile: A study on cross country skiers, swimmers, long-distance runners and soccer players. A retrospective 12-m…
2009
This 12-month retrospective questionnaire compared the occurrence of sports injuries in 149 cross country skiers, 154 swimmers, 143 long-distance runners and 128 soccer players aged 15-35 years. Soccer had significantly more injuries (5.1 injuries/1000 exposure hour) than other sports (2.1-2.8, P<0.001). More runners than soccer players reported overuse injuries (59% vs 42%, P=0.005), locating typically in the foot in runners, soccer players and skiers. Swimmers reported overuse injuries in the shoulder more commonly than skiers (40% vs 1%, P<0.001), who also intensively load shoulders. Acute injuries in skiers (80%) and in swimmers (58%), and overuse injuries in skiers (61%), occurred duri…
A phase I-II study of cyclophosphamide, epidoxorubicin, levofolinic acid/5-fluorouracil and recombinant human granulocyte colony stimulating factor i…
1994
Thirty patients with measurable metastatic breast carcinoma were treated with a combination of cyclophosphamide 600 mg/m2 on day 1, levofolinic acid 100 mg/m2 plus 5-fluorouracil 375 mg/m2 on days 1-3, and epidoxorubicin (EDXR) in three refracted doses on days 1-3 with G-CSF rescue for 10 days. In the phase I part of the study, groups of 3 patients received EDXR 20, 25, 30, 35, and 40 mg/m2/day until the dose limiting toxicity (DLT) was reached. At the dose of 40mg/m2/day prolonged grade 4 leukopenia, severe proctitis, and grade 3 diarrhea represented the DLT. All subsequent partients were treated at the maximal tolerated dose of EDXR (35 mg/m2/day). In the group of 18 patients treated at 3…
Measurement of energy expenditure by activity monitors: is it feasible to measure energy expenditure using tiny portable monitors?
2013
Physical inactivity has a major health effect worldwide. It is stated in the currently published physical activity recommendations for adults to promote and maintain health, that all healthy adults need moderate intensity physical activity for a minimum of 30 minutes, 5 days per week or vigorous intensity aerobic physical activity for a minimum of 20 minutes, 3 days per week. Physical activity can be defined as any bodily movement produced by the contraction of skeletal muscles that substantially increases energy expenditure and is characterised by its intensity, duration, frequency and mode of activity. Ideally, all these aspects should be recorded during physical activity measurements. Ho…
Effects of different backpack loads in acceleration transmission during recreational distance walking
2013
It is well established nowadays the benefits that physical activity can have on the health of individuals. Walking is considered a fundamental method of movement and using a backpack is a common and economical manner of carrying load weight. Nevertheless, the shock wave produced by the impact forces when carrying a backpack can have detrimental effects on health status. Therefore, the aim of this study was to investigate differences in the accelerations placed on males and females whilst carrying different loads when walking. Twenty nine sports science students (16 males and 13 females) participated in the study under 3 different conditions: no weight, 10% and 20% body weight (BW) added in …
Long-term effects of graduated compression stockings on cardiorespiratory performance
2015
ABSTRACT: The use of graduated compression stockings (GCS) in sport has been increasing in the last years due to their potential positive effects for athletes. However, there is little evidence to support whether these types of garments actually improve cardiorespiratory performance. The aim of this study was to examine the cardiorespiratory responses of GCS during running after three weeks of regular use. Twenty recreational runners performed three tests on different days: test 1) ¿ a 5-min maximal effort run in order to determine the participants¿ maximal aerobic speed; and tests 2) and 3) ¿ a fatigue running test of 30 minutes at 80% of their maximal aerobic speed with either GCS or PLAC…
Match analysis of wheelchair padel players of different functional level
2018
The aim of this study was to quantify the kinematic demands of wheelchair padel and to examine the activity profiles in professional players according to their functional level. Twenty-two elite players classified in functional level groups (from 1 to 4) were video-analysed with a two-dimensional DLT corrected video system across seven matches of a professional tournament. The results showed players covered 729.6 ± 369.9 meters and 238.45 ± 129.45 turns per match during 1128.9 ± 583.04 second of effective playing time at a mean speed of 0.53 ± 0.49 m/s per rally. The WCP players’ functional classification had heavy influence on their activity profiles during matches, with a large associatio…
The use of same in chemotherapy-induced liver injury
2018
Drug-induced liver injury (DILI) remains the most common cause of acute liver failure in the Western world. Chemotherapy is one of the major class of drugs most frequently associated with idiosyncratic DILI. For this reason, patients who receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate and which drug doses should be modified. S-adenosylmethionine (SAMe) is an endogenous agent derived from methionine. Its supplementation is effective in the treatment of liver disease, in particular intrahepatic cholestasis (IHC). The target of this review is to analyze the mechanisms of hepatotoxicity of the principal antican…